Uno is played with a special deck of 108 cards. Players take turns matching a card in their hand to the top card of the discard pile by color or number. Special cards like Skip, Reverse, Draw Two, and Wild add twists. The goal is to be the first to play all your cards. When a player has one card left, they must shout 'Uno!' The game ends when one player has no cards left. Uno is fast-paced, easy to learn, and perfect for quick, fun matches.